094
ELEMENTS OF MATERIA MEDICA.
jgred
3. Red Cinchonic ( Insoluble Red Colouring Matter). —This substance is c ^ nS j s t ofby Berzelius (op. cit.) to be a product of tannin altered by the air, and to j t istannin and apotheme. It is inodorous, insipid, and of a reddish brown coin ^' ffa ter.insoluble, or nearly so, in cold water, but is somewhat more soluble in boin' butAcids favour its solution in water. It is soluble in alcohol (especially ' vhe " aC ;J l thescarcely so in ether. Its aqueous solution has not, either with or without an ^tar-power of formin'*' a precipitate with a solution of gelatine, but it has with eme - {3 te<lIf, however, red cinchonic be dissolved in an alkaline solution, and then P re . „jtb aby an acid, it acquires the power of precipitating gelatine. But if it be hea thesolution of potash or soda, it loses the power of precipitating gelatine. , g latt-nlow-pipe red cincliouic conducts itself as an animal substance ( Pharm .
f ur 1832, S. 391). . - ona barf*
4. Kinic, Cinchonic, or Quinic Acid . —This acid is not peculiar to the cmci . Asbeing also found, according to Berzelius , in the alburnum of Abies conMf ^icbmet with in commerce, kinic acid is in the form of a thick syrupy 1><1 U1 , a ] c ohoJ’maybe crystallized, though with difficulty. It is soluble both in water *u
and has an acid taste. When heated in closed vessels, it is decomposed,— aC jd,acid is formed,—and an odour of caramel evolved (like that of sugar or tar ^ 0 f
when heated). Sulphuric acid dissolves it, acquires a green tint, and by 1 0 r tb«l—, i : t. i _,_»i_i-;-1._ of silver*
It does not precipitate the calcareous salts, nitrate m “** j^^-iity <
of
heat, carbonizes it
neutral acetate of lead ; but it precipitates the diacetate of lead. In the by i* 9its combinations it is analogous to acetic acid, from which it is distinguis ^ u5 t ocrystallizability, and its not volatilizing unchanged. The Kinates are ana °o ^eOthe acetates in their solubility in water: they are insoluble in pure alcoho ■ 0 doUfdried, they have a gummy appearance ; and when decomposed by heat, evolve p r e-
of caramel. Pyrokinic acid does not precipitate the alkalies, lime, or barytes. t |,e
cipitates the salts of lead and silver; and lastly, it gives a beautiful green com a tom' csalts of iron. Kinic acid consists, according to Liebig, of C 15 H9 O 9 : r ^weight, therefore, is 171. Baup represents its composition to be C 15 H 10 ’
is identical with that of lignin, according to IVout. • . ; n cli° lia
nova i
light substance, very little soluble in water, but readily dissolved by aicouu. —- p .
A solution of Icinovate of magnesia forms precipitates ( kinovates ) with solutionstate of lead, bichloride of mercury, and the salts of cinchonia. obs erv3 J
6. Cinchona Alkalies ( Cinchonia , Quinia, and Aricina ).—It appears from , ,j a a®“tious of Henry and Plisson ( Journ. de Pharm. xiii. 269 and 369) that cum 1 ^ c in-quinia exist in cinchona bark in combination with kinic acid, and also with j. s is
clmnic. The quantities of cinchonia and quinia yielded by some cinchona g e n,
thus stated by Soubeiran (Traite de Pharm. i. 603) and by Yon SantenMonograph. PI.),—Goebel’s table has been already (p. 993) given,—:
1 . Uncoated Yellow (Calisava)Bark
2 . Coated
Bark
3. Loxa Bark
Yellow (Calisaya)
4. Gray (Lima) Bark
5. Beep Red Bark_
6. Pale Red Bark
7. Spongy Carthagcna Bark
202 to 218 grs.of Sulphate ofQuinia.
177 grs. of ditto.
83$ to 118 grs.of Sulphate ofCinchonia.
SS£ grs. of ditto.
118 grs. of Sul-phate of Qui-nia, and 59grs. of Sul-phate of Cin-chonia.
88J grs. of Sul-phate of Qui-nia, and 59grs. of Sul-phate of Cin-chonia.
19i to 29J grs.of Sulphate ofCinchonia.
According to Von Santen ^ ^
in$-a ah
One lb. (Apoth . Weight). Apoth-
1 . Coated Yellow (Calisaya) Bark 160 Q«i-
pnai* j a cr(&•
Eia. and^-jn-
nia, Ci®'of P urechon^ptu
2. Loxa Bark. 53 * 0 ?tt oi “f pur*
3. Gray (Huanuco) Bark. 3l< C^wb°n’pure
4. Red Bark . 184 cfncii<>"i^ub
9 Pf- Rui-phatenia- 0 f
5. Hard Carthagena Bark .
6. Fibrous Carthagena Bark -
30 S rS -t,nni3' V
Cinctiou' , u |.
32 P*-° ( a®*'
pliate ot “iiia. ( pure
04 TTS. ° { J S3 Cinction' f ‘i 0 l-
30<Coi aui '
phate oi
7. Iiuamalies Bark
hi*- n f pur e
95 c%>
8. Asli-Cinchona Bark. 1 of*Qui n * a '
9. False Loxa Bark