GAMBOGE HEBRADENDRON.

1231

hors e / caus ed dysentery, which continued seventeen days. On thesoft 10 S1X *° ^ we ^ v ’ e drachms have merely rendered the stools some-gularity 7 and more frequent, although shivering, loss of appetite, irre-to Uis \‘ v ° P u ^ se ) great anxiety, and other alarming constitutional symp-Wd', bought on (Moiroud, Pharm. Vet. p. 267-8). On the otherano’ nc lbor g (Wibmer, Wirk. der Arzneim. ii. Gifte. ii. 389) has given(J_) q fr' ihe horse without any remarkable effect,of t}, e y man <—Taken in small doses, gamboge promotes the secretionsand i; n a .\ mentar y canal and of the kidneys, and causes more frequentoft—" Ul d stools than natural. In larger doses it occasions nausea,

oft.

e^d j* v °miting, griping pains of the bowels, watery stools, and in-?te a t de 1Sc , r S e of urine. When the action is very violent, there is®n acr ^P res sion of the vascular system. In excessive doses it acts asWed h P 018011, A drachm caused horrible vomiting and purging, fol-P. l3g\ ^ ^yocope and death (Paullini, Eph. Nat. Cur. Dec. i. Ann. viii.qua nti : ihe deaths which have occurred from the use of enormous* v ii, °P Morison’s pills (see Lond. Med. Gaz. vol. xiv. 612 and 759;tribal,] 4l5j and 623 ’ xviii. 75 and 927; and xix. 976) are mainlyc ase s t jj e e to ’-Pe gamboge contained in these medicines. In these

fg , symptoms were, violent vomiting and purging, abdominal paineSat »inap rneS - S> ctdd extremities, and sinking pulse. On post-mortem"'ere found 0 ’ * ndamina d° n > ulceration, and mortification of the intestines,

ae'tivq^ 6 . W^ on S 8 t° the active hydragogues and drastic purgatives.Map s 1S ^ n fr r i°r to elaterium and croton oil. In acridity it exceeds"Hied to am “ on y> and even colocynth. In its mode of operation it isa pt to; ’. though scarcely so acrid as, euphorbium. It is exceedinglya hse$ f r ri , e the stomach, and to occasion nausea and vomiting. ThisW sto r ' )m ,’ts ready solubility in the gastric juices. As this action onl(, ss en j ac h is exceedingly objectionable, we sometimes endeavour toW S q 1 , y Con j°iuing aloes, or some other substance which diminishes1,1 the f 1 0 gamboge in aqueous fluids, and by giving the medicine

^inb 0 ,, e ° ri11 <d Pdh Sundelin ( Heilmittell, ii. 28, 3“ Aufl.) ascribes tov? >Us) of tv, 0 es P e(da l power of exciting the vascular system (arteries andl ° the he 10 P el . vic organs, in virtue of which, he says, it readily gives risefardg d raorr hoidal flux and uterine hemorrhage. Furthermore, he re-^Pecialf aS ,P ower fully instating and exciting to the abdominal nerves,Wes sa cral and pelvic divisions,evid br ° m *-h e foregoing account of the effects of gamboge, it is"e abd 0 ^ h is a remedy well adapted for acting as a stimulus toWe, or t 1 ■ and P e h'i c viscera, either to rouse them when in a torpidWant o ° ® lve t 'h°m preternatural activity, and thereby to relieve some. e Use of 8 ^’ ° n dle principle of counter-irritation. On the other hand,!^ a UiiUat “ ambo g e is highly objectionable when there is an irritable orl °ti, or t0 ° ry c ( ont hli° n of the stomach or bowels, a tendency to abor-0f hicre as Ut ^ r ^ ne hemorrhage, and also when we do not want to promotec " s es j n .J! . hemorrhoidal discharge. The following are some of the1. p n hich we employ it:—

^hoa^°- mi ^ a ^ on } where an active cathartic of small bulk is required,

, ° s e wVl\ em Pl°y ed - ^ i s > however, not given alone, as the necessarys 1al] y c .6 very apt to create nausea and vomiting. It is, therefore,Joined with other and milder purgatives, the operation of