1398

ELEMENTS OF MATERIA MEDICA.

ill k

it. In 1820, Blondeau and Guibourt ( Joum . de Pharm. vi. A jtilished an analysis of it. Afterwards, Westler (Buchner’s Rep- . ;l n<iS. 222. 1824), Buchner [Ibid. Bd. xxii. S. 152. 1825), andIleinmann (Gmelin, Handb. d. Chem. ii. 1449), submitted it to cinvestigation.

46 9250-325

13 000

Guibourt and Blondeau,

1. Volatilized by Sinter ....

drying l Ammonia ..

2. Extracted by ether —Stearine,

oleine, cholesterine, fattyacid with ammonia, tracesof a volatile oil —.

3. Extracted subsequently by

alcohol —Cholesterine , fattyacid with ammonia, salammoniac, chlorides of po-tassium, sodium, and cal-cium, and an undeterminedacid combined with thesame bases. 6 000

4. Extracted subsequently by

watei —Gelatine, carbona-ceous matter soluble inwater, the preceding- chlo-rides, and an undeterminedcombustible acid . 19-000

5. Extracted subsequently by

ammonia — Albumen and

phosphate of lime . 12-000

Fibrous tissue, carbonate andphosphate of lime, hairs,and sand . 2-750

6 .

100000

Odorous Principle .—Has not hitherto been isolated.

Geiger and Reinmann •

1. Peculiar volatile substance- _j ll3 i

tity undeter p- tt o

2. Ammonia .

3. Peculiar, fixed, uncrystalu 2 pjttn

ble acid. 1*

4. Stearine and oleine.....••••■

5. Cholesterine (with s0

oleine and resin) ." 5^

6. Peculiar bitter resin .■ '

7. Osmazome (with sal an J® m

niac, chlorides of sod®_and calcium, and the aboacid, partly free, p af G focombined with the basesy^

8. A mouldy-like substance, ^

part combined with aDinI i enia, by which it is 1113 ,jsoluble in water, with soi ^quantities of phosphateslime and magnesia, ?phate of potash, chlorid®of potassium and sot lll j a ’carbonate of potash or so ’and trace of iron.'

9. Sand . •.••■‘V nlis

10. Water, some volatile odor

matter, the above aCI<1 .. ,

part combined with a® ^ 40nia, and loss .

J00°

The strong and tliff ll? 'y e t

volatile-. „ t bt>ofc

O'*

of musk would lead us to expect that its odorous matter was highly volatu • t |is not the fact; for we cannot deprive musk of its peculiar odour by distilla 0 b' , ' l ’c l ||!the distilled liquid has a musky smell. As it is destructable by heat, ll ^ jnaloej^organic. It is not peculiar to musk, since many other substances exhale a (a , f >sodour. Some have suggested that it is the result of putrefaction of one or ^constituents of musk ; and in support of this statement it is asserted l] . rit L rcP eat „,4

method of desiccation, musk may be dried and rendered odourless. I ^ l!lVe 1 A

r 1 ,1 • • , • 1* 1 • . 1 . 1 . • ■

ref

performed this experiment with every care, but without obtaining a

Robiquet was of opinion that many odorous substances owed their odou Il0 t ob_. [0quantity of ammonia, which, being disengaged, carried off with it substaii t |,eS - jwise volatile, which masked the ammoniacal smell. In applying this Ayui* 19 jjimusk, it must be admitted that it harmonizes well with several of the ®observed. Thus musk evolves ammonia ; water distilled from m usk c0 ! lta . 1 t j ] e e v °

and potash added to a solution of musk heightens its odour (by facilitationof ammonia ?).

d

• mI(1 . A .il'

Physiological Effects. —Musk disturbs the functionsacts as a stimulant to the vascular system and brain, any ^

proves narcotic. Jorg ( Material. zu einer Argneimittell.

i. p. 952), and his pupils subm 1 yji*

and Lond. Med. Gaz. vol. xxviselves to its inlluence

of from 2 to 15 grains m w

ater