CINCHONA. 1007

t '-»)m U ^ 0US ^’ rc gulated doses; secondly, there are two inodes of at-iini tl ’ 1 i n ^ Hre cure of an intermittent by cinchona,—one is to put angiv en late stop to the disease by the use of very large doses of the remedyto ,, r ^ ew hours prior to the recurrence of the paroxysm,—the other isat a. ( " all y extinguish the disease by the exhibition of moderate dosesthe v; ^ intervals during the whole period of the intermission, so that

of

^oleiice of every succeeding paroxysm is somewhat less than that•ttetWi ; Pre ? edill S one ;—but in the case of arsenious acid the latterIt ] 1S apllle sa f e and, therefore, to be adopted,of an ! as been asserted that cinchona is admissible in the interval onlyit ] las lute nnittent fever; and that if it be exhibited during the paroxysmir l (.r ll ■ a Pudency to prevent the subsidence of the latter. But this state-

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*ej,

ft %

•is

al

much overcharged. Morton ( Pyretologia ) and others have given

most every stage without injury.+Utc~‘ '

sio a ^ a ^ u g the bark even in the middle of the fit is, that it might occa-SlC ^ ness ’ an( l might harass the patient by being vomited up, andititety f et p un against it.” It is, however, more efficacious during thep Ull e a ’ though it may not be absolutely hurtful in the paroxysm. Ilr.

Med. ii. 96) was strongly of opinion that the nearer thetajyj lon of the cinchona is to the time of accession, the more cer-lci<p n e dectual will it be. I have already stated (p. 392) that arseniousHud j la y be given with good effect during the whole period (paroxysm,\ er mission) of the disease.

th e st er y necessary condition to its perfect success is that it sit well onto a c t°] ,llac k ’ p)r if it occasion vomiting or purging it is much less likelyto , beneficially. Hence an emetic and a purgative are recommendedsa r y ®. Ce de its employment. The use of these is more especially neces-anh a dle disease be recent. For an adult about 15 grains of ipecacu-tiii) ei ,'"d 1 a grain of tartarized antimony may be exhibited as an emetic,

^ rr>1 -) observes, “ the only harm

Hr. Heberden ( Comment . art.which 1 believe would follow

'■U'-SS 0*“*“ VI - J - J -- . ^

tio n of lll ® re he symptoms of determination to the brain, or of inflamma-a »,Ji tlle digestiv(of Purgative .

A senna draught, with a calomel pill, formsTo enable it to sit well on the stomach, cinchona

e organs.

^ sulphate of cpiinia) is frequently given in conjunction with aro-fiv e ‘) I'hc infusion or decoction of cinchona, though much less effec-c tecl) re ’ however, less liable to disturb the stomach than the powder of; ul 1Uli y or the sulphate of quinia. Opium is sometimes a necessary

c a$e s 10 c hichona to prevent its running off by the bowels. In someof ci n "i eie die stomach was too irritable to admit of the administrationoth^ona or sulphate of quinia by the mouth, these agents have beenU:s e ,| | lSc introduced into the system. Thus clysters of cinchona werej'olvctius, Torti, and Baglivi (MuiTay, App. Med. i. 871). VanOes S f U |b (Commentaries, vii. 277) says he has often seen this method suc-Av °Ul(l ln y° un g children; but that it takes three times as much bark as0ls o ^ Sll ffice if the remedy were swallowed. Cataplasms of cinchona havedie w 011 ein ployed. Rosenstein applied them to the abdomen ; Torti toag ue ,-t (Murray, op. cit. 872). Alexander ( Exper. Essays, 38) cured antried ijf v J lc< Cduvium of decoction of cinchona ; but Ileberden {Comment.)the "tehout success. Bark jackets were employed with success inc <>tisij^ U< j s °f children by Hr. Pye {Med. Ohs. and Inq. ii. 245). Theyd ,l 'Uo(] "’aistcoats between whose layers powdered cinchona wasThe dry powder of cinchona has been epplied to the skin: